Lecturer at the Department of Pathology, Basic and Clinical Pharmacology Seitov T.S. conducted a lesson for 2-eng to 11A -group in off-line mode using the problem-based teaching method. Students analyzed problem situations in the lesson, cases, tasks. Students actively interacted and looked for a solution to get out of the situation. They were happy, the lesson was interesting. It should be noted that the teaching staff of the department widely uses Pbl, Cbl, Tbl, Rbl methods in teaching students. This lesson structure works to motivate them to learn.